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Coadministration may cause serotonin syndrome Do not use concomitantly or initiate bupropion within 14 days of stopping an MAOI Converselyat least 14 days should be allowed after stopping bupropion before starting an MAOI antidepressant Starting bupropion in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased risk of serotonin syndrome If linezolid or IV methylene blue must be administereddiscontinue bupropion immediately and monitor for CNS toxicitymay resume 24 hr after last linezolid or methylene blue dose or after 2 weeks of monitoringwhichever comes first.

DisclaimerOur goal is to provide you with the most relevant and current informationHoweverbecause drugs interact differently in each personwe can not guarantee that this information includes all possible interactionsThis information is not a substitute for medical adviceAlways speak with your healthcare provider about possible interactions with all prescription drugsvitaminsherbs and supplementsand over-the-counter drugs that you are taking.

Begin therapy 1 week before target quit dateusually second week of treatmentMay be combined with the use of the nicotine patch.

Assess blood pressure before initiating treatment with sustained release formulationand monitor periodically during treatmentrisk of hypertension is increased if sustained release formulation is used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activityuse caution in people with cardiovascular disease.

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